Department of Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Cell Immunol. 2010;263(2):148-53. doi: 10.1016/j.cellimm.2010.02.009. Epub 2010 Mar 10.
A regulatory or suppressor T cell is functionally defined as a T cell that inhibits an immune response by influencing the activity of another cell type. On the other hand, Th1 cells express IFN-gamma and mediate cellular immunity. Sclareol exhibits growth inhibition and cytotoxic activity against a variety of human cancer cell lines. In the first set of experiments, Sclareol was isolated from the plant Salvia sclarea and our study assessed the immuno-therapeutic effectiveness of Sclareol by direct intra-tumoral injection. Secondly, several immunological parameters such as splenocytes proliferation, intra-tumor CD4+CD25+Foxp3+ Treg cells, IFN-gamma and IL-4 secretion and tumor size were assessed to evaluate the anti-tumoral immune response. By all means, the findings confirmed that the activity of Sclareol could reduce the tumor growth in vivo against breast cancer.
调节性或抑制性 T 细胞是通过影响另一种细胞类型的活性来抑制免疫反应的 T 细胞，其功能定义。另一方面，Th1 细胞表达 IFN-γ并介导细胞免疫。鼠尾草醇对多种人癌细胞系表现出生长抑制和细胞毒性活性。在第一组实验中，鼠尾草醇从植物 Salvia sclarea 中分离出来，我们的研究通过直接瘤内注射评估了鼠尾草醇的免疫治疗效果。其次，评估了几种免疫参数，如脾细胞增殖、肿瘤内 CD4+CD25+Foxp3+Treg 细胞、IFN-γ和 IL-4 的分泌以及肿瘤大小，以评估抗肿瘤免疫反应。无论如何，研究结果证实，鼠尾草醇的活性可以减少体内乳腺癌的肿瘤生长。
