Hennings T, Hennings D, Lindsay C
Colorado State University, Fort Collins, Colorado 80521.
Phlebology. 2014 Apr;29(3):171-8. doi: 10.1177/0268355512473921. Epub 2013 May 6.
The purpose of these experiments was to simulate thrombus formation during endovenous laser closure by measuring coagulum formation of in vitro laser exposures in porcine blood and investigate the role of procedures and equipment in thrombus formation.
Continuous wave 810, 940, 980, 1310 and 1470 nm lasers and microsecond pulsed wave 1064 nm Nd:YAG (neodymium-doped yttrium aluminium garnet), 1320 nm Nd:YAG and 2100 nm THC:YAG (thulium holmium chromium-doped yttrium aluminium garnet) lasers were tested with standard fibres with diameters of 365, 550 and 600 μm as well as two prototype modified tip fibres.
The results show that pulsed lasers with high-peak power densities form less coagulum. Fibre specifications were found not to influence coagulum formation, and prototype modified tip fibres designed to prevent contact between the fibre tip and the vein wall did not eliminate coagulum formation.
Microsecond-pulsed wave lasers with high-peak power densities may be a better choice to minimize soft thrombus formation during endovenous laser ablation treatments.
这些实验的目的是通过测量猪血液体外激光照射后的凝块形成，来模拟静脉内激光闭合过程中的血栓形成，并研究操作和设备在血栓形成中的作用。
测试了连续波810、940、980、1310和1470 nm激光以及微秒脉冲波1064 nm Nd:YAG（掺钕钇铝石榴石）、1320 nm Nd:YAG和2100 nm THC:YAG（掺铥钬铬钇铝石榴石）激光，使用直径为365、550和600μm的标准光纤以及两种原型改良尖端光纤。
结果表明，具有高峰值功率密度的脉冲激光形成的凝块较少。发现光纤规格不影响凝块形成，并且设计用于防止光纤尖端与静脉壁接触的原型改良尖端光纤并未消除凝块形成。
具有高峰值功率密度的微秒脉冲波激光可能是在静脉内激光消融治疗期间使软血栓形成最小化的更好选择。
