Amin Adnan, Khan Muhammad Ayaz, Shah Swahid, Ahmad Mushatq, Zafar Muhammad, Hameed Abdul
Gomal University, D.I. Khan, Pakistan.
Pak J Pharm Sci. 2013 Mar;26(2):251-4.
This work aimed to evaluate the inhibitory effects of Olea ferruginea crude leaves extract that are commonly used as remedy to cure infections in the tribal (Khyber Agency) areas of Pakistan against some of bacterial and fungal pathogens. The crude n-hexane fraction was appreciably active against both gram positive and negative microorganisms (MIC ranged from 7.5 to 15 mg/ml) followed by butanol fraction (MIC 15 to 30 mg/ml). Conversely least biological activity was shown by chloroform (30mg/ml) and methanol (15 to 30mg/ml) crude fractions. The MBC observed for all crude fractions was same or 2 times higher when compared with MIC for all crude extract fractions. Likewise all the fractions showed activity against Aspergillus niger and maximum zones of inhibition were shown by the n-hexane fraction (14 ± (0.02), butanol (13 ± (0.02) followed by methanol (9 ± (0.05) and chloroform fractions (7 ± (0.02). These results clearly imitate the antibacterial and antifungal potential of Olea ferruginea and hence we recommend the whole plant for further futuristic studies.
这项工作旨在评估锈叶油橄榄粗叶提取物对一些细菌和真菌病原体的抑制作用，该提取物在巴基斯坦部落地区（开伯尔部落特区）常被用作治疗感染的药物。正己烷粗提物对革兰氏阳性和阴性微生物均有明显活性（最低抑菌浓度范围为7.5至15毫克/毫升），其次是丁醇提取物（最低抑菌浓度为15至30毫克/毫升）。相反，氯仿（30毫克/毫升）和甲醇（15至30毫克/毫升）粗提物的生物活性最低。与所有粗提物部分的最低抑菌浓度相比，所有粗提物部分的最低杀菌浓度相同或高出2倍。同样，所有部分对黑曲霉均有活性，正己烷部分（14±（0.02））显示出最大抑制圈，其次是丁醇部分（13±（0.02））、甲醇部分（9±（0.05））和氯仿部分（7±（0.02））。这些结果清楚地表明了锈叶油橄榄的抗菌和抗真菌潜力，因此我们建议对整株植物进行进一步的未来研究。
