关于甲状腺功能亢进大鼠肝脏和心脏中D-3-羟基丁酸脱氢酶活性降低的情况。
Concerning the decreased D-3-hydroxybutyrate dehydrogenase activity in the liver and heart of hyperthyroid rats.
作者信息
Lippolis R, Morini P, Conserva A R, Casalino E, Landriscina C
机构信息
Research Unit on Mitochondria and Energy Metabolism, National Research Council, Bari, Italy.
出版信息
Mol Cell Biochem. 1990 Mar 27;93(2):147-52. doi: 10.1007/BF00226186.
Whereas in rat liver mitochondria the hyperthyroid state causes an increase both in fatty acid unsaturation and in the Ea of D-3-hydroxybutyrate dehydrogenase and a decrease in phase transition temperature, in hyperthyroid rat heart mitochondria these changes are negligible. D-3-hydroxybutyrate dehydrogenase in both the liver and the heart mitochondria of hyperthyroid rats is reduced by about 35% [12] but this reduction is not due to changes in membrane fluidity in either tissue. Hypothyroidism, on the other hand, affects BDH activity in neither heart nor liver.
在大鼠肝脏线粒体中，甲状腺功能亢进状态会导致脂肪酸不饱和度增加、D-3-羟基丁酸脱氢酶的活化能增加以及相变温度降低，而在甲状腺功能亢进的大鼠心脏线粒体中，这些变化可以忽略不计。甲状腺功能亢进大鼠的肝脏和心脏线粒体中的D-3-羟基丁酸脱氢酶均降低约35%[12]，但这种降低并非由于任何一种组织中膜流动性的变化。另一方面，甲状腺功能减退对心脏和肝脏中的BDH活性均无影响。
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