大鼠肝脏和心脏线粒体β-羟基丁酸脱氢酶的动力学
The kinetics of rat liver and heart mitochondrial beta-hydroxybutyrate dehydrogenase.
作者信息
Tucker G A, Dawson A P
出版信息
Biochem J. 1979 Jun 1;179(3):579-81. doi: 10.1042/bj1790579.
Abstract
The kinetic mechanisms of the beta-hydroxybutyrate dehydrogenase from rat heart and liver mitochondria were investigated. Both enzymes, show an Ordered Bi Bi mechanism and there are no major differences in the kinetic constants. In both cases, the solubilized enzyme, re-activated with phosphatidylcholine, shows kinetic properties very similar to those of the enzyme bound to the mitochondrial membrane.
摘要
对大鼠心脏和肝脏线粒体中β-羟基丁酸脱氢酶的动力学机制进行了研究。这两种酶均表现出有序的双底物双产物机制，动力学常数没有显著差异。在这两种情况下，用磷脂酰胆碱重新激活的可溶性酶表现出与结合在线粒体膜上的酶非常相似的动力学性质。
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本文引用的文献
1
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J Biol Chem. 1960 Aug;235:2450-5.
2
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Biochim Biophys Acta. 1963 Feb 12;67:188-96. doi: 10.1016/0006-3002(63)91816-x.
3
The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.具有两种或更多种底物或产物的酶催化反应动力学。I. 命名法和速率方程。
Biochim Biophys Acta. 1963 Jan 8;67:104-37. doi: 10.1016/0006-3002(63)91800-6.
4
Graphical determination of the dissociation constants for two-substrate enzyme systems.双底物酶系统解离常数的图形测定法。
Biochim Biophys Acta. 1957 Sep;25(3):575-8. doi: 10.1016/0006-3002(57)90529-2.
5
Chloride-hydroxide exchange across mitochondrial, erythrocyte and artificial lipid membranes mediated by trialkyl- and triphenyltin compounds.由三烷基锡和三苯基锡化合物介导的跨线粒体、红细胞及人工脂质膜的氯-氢交换。
Eur J Biochem. 1970 May 1;14(1):120-6. doi: 10.1111/j.1432-1033.1970.tb00268.x.
6
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7
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8
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J Biol Chem. 1973 Apr 10;248(7):2556-62.
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