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Evaluation of genotoxicity of clofazimine, an antileprosy drug, in mice in vivo. II. Micronucleus test in bone marrow and hepatocytes.

作者信息

Roy B, Das R K

机构信息

Environmental Mutagenesis Unit, School of Life Sciences, Sambalpur University, Orissa, India.

出版信息

Mutat Res. 1990 Jun;241(2):169-73. doi: 10.1016/0165-1218(90)90121-h.

DOI:10.1016/0165-1218(90)90121-h
PMID:2345555
Abstract

The antileprosy drug, clofazimine, was tested for its possible genotoxicity using micronucleus (MN) tests in mice. A significantly higher incidence of MN in bone marrow erythrocytes, particularly in polychromatic erythrocytes, as well as in regenerated hepatocytes revealed a positive clastogenic effect of the drug. The drug also had a marked antimitotic effect as indicated by a negative correlation with the dose.

摘要

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