Hatta S, Duni A, Ng C G, Lin N, Marhani M, Das S, Nik Ruzyanei N J
Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, Bandar Tun Razak, Kuala Lumpur, Malaysia.
Clin Ter. 2013;164(1):11-5. doi: 10.7417/T.2013.1503.
Depression and its treatment may influence all aspects of the female sexual function from desire to sexual satisfaction. This study aimed to examine the components of the female sexual response cycle (SRC) of women with major depression treated with Selective Serotonin Reuptake Inhibitors.
The correlations structure of the items of the SRC's phases (i.e. desire, arousal, orgasm, satisfaction and pain) in a validated Malay version of Female Sexual Function Index (FSFI) was determined using principal component analysis (PCA), with varimax rotation method. The number of factors obtained was decided using Kaiser's criteria. Factor loadings using PCA with varimax rotation divided the sexual domains into three components based on Kaiser's criteria.
Sexual desire, sexual arousal, lubrication and orgasm were highly correlated, to form a "sexual drive" construct. Sexual satisfaction and pain made up the second and third components, respectively. SSRIs may affect the components of the SRC causing highly overlapping constructs of sexual drive including orgasm. Recognizing this helps strategizing the treatment approach of female sexual dysfunction in depression particularly in relation to the role of SSRIs.
抑郁症及其治疗可能会影响女性性功能从性欲到性满足的各个方面。本研究旨在探讨接受选择性5-羟色胺再摄取抑制剂治疗的重度抑郁症女性的性反应周期（SRC）的组成部分。
使用主成分分析（PCA）及方差最大化旋转法，确定经过验证的马来语版女性性功能指数（FSFI）中SRC各阶段（即性欲、唤起、高潮、满足和疼痛）项目的相关结构。根据凯泽准则确定所获得的因子数量。采用PCA及方差最大化旋转法得出的因子载荷，根据凯泽准则将性领域分为三个组成部分。
性欲、性唤起、润滑和高潮高度相关，形成一个“性驱力”结构。性满足和疼痛分别构成第二和第三个组成部分。选择性5-羟色胺再摄取抑制剂可能会影响SRC的组成部分，导致包括高潮在内的性驱力结构高度重叠。认识到这一点有助于制定抑郁症女性性功能障碍的治疗策略，特别是与选择性5-羟色胺再摄取抑制剂的作用相关的策略。
