Walker W G, Hermann J, Murphy R P, Russell R P
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md.
Nephron. 1990;55 Suppl 1:21-6. doi: 10.1159/000186030.
Longitudinal data were obtained on 131 diabetic subjects enrolled in a study designed to evaluate the impact of persistent elevation of the blood pressure (BP) upon progression of renal damage in diabetes mellitus. For both insulin-dependent and non-insulin-dependent diabetes, serum creatinine exhibited a more rapid rise in those individuals whose BP remained elevated above 140 mm Hg despite therapy. Since no significant difference in age, duration of diabetes, diabetic control, or renal function at entry in the study could be identified as possible explanations for these differences, the findings support the conclusion that persistent elevation of the BP adds significantly to the risk of renal damage in both insulin-dependent and non-insulin-dependent diabetes, with more rapid decline occurring in non-insulin-dependent diabetes. Hypertensive subjects exhibited higher levels of plasma angiotensin II during the follow-up period.
对131名糖尿病患者进行了纵向数据收集，这些患者参与了一项旨在评估血压持续升高对糖尿病患者肾脏损害进展影响的研究。对于胰岛素依赖型和非胰岛素依赖型糖尿病患者，尽管接受了治疗，但血压仍高于140 mmHg的个体血清肌酐升高更快。由于在研究开始时，年龄、糖尿病病程、糖尿病控制情况或肾功能方面没有显著差异可作为这些差异的可能解释，这些发现支持以下结论：血压持续升高显著增加了胰岛素依赖型和非胰岛素依赖型糖尿病患者肾脏损害的风险，非胰岛素依赖型糖尿病患者的肾功能下降更快。高血压患者在随访期间血浆血管紧张素II水平较高。
