Chastel C, Chastel A
3, rue Rouget de l'Isle, 29200, Brest, France.
Bull Soc Pathol Exot. 2013 May;106(2):126-30. doi: 10.1007/s13149-013-0280-2. Epub 2013 Feb 28.
By 1926, two French physicians working in Indochina, R. Pons and L. Chastel, have suggested to treat leprosy by subcutaneous injections of bacillus Calmette-Guerin. This treatment appeared efficient since the lepromatous lesions quickly regressed and the Hansen bacillus disappeared from the nasal mucus. These results were quickly confirmed by other authors. They were all more appreciated than, at this time, the Chaulmoogra oil and its products, the only available drugs, were poorly efficient against the disease. Nevertheless, although not a panacea, the BCG therapy allowed to relieve these unfortunate patients until the beginning of the 1950's when an effective treatment by sulfones was at length available.
到1926年，两位在印度支那工作的法国医生R.庞斯和L.沙斯泰尔建议通过皮下注射卡介苗来治疗麻风病。这种治疗方法似乎很有效，因为瘤型麻风病变迅速消退，汉森氏杆菌从鼻黏液中消失。这些结果很快得到了其他作者的证实。与当时唯一可用的药物大风子油及其制品相比，它们都更受青睐，因为大风子油及其制品对这种疾病的疗效很差。然而，尽管卡介苗疗法不是万灵药，但它能让这些不幸的患者得到缓解，直到20世纪50年代初终于有了有效的砜类药物治疗方法。
