Department of Nuclear Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd., Shanghai, 200040, People's Republic of China.
Clin Exp Med. 2014 May;14(2):225-33. doi: 10.1007/s10238-013-0234-9. Epub 2013 Mar 3.
Pancreatic cancer has the worst prognosis of any gastrointestinal cancer, with the mortality approaching the incidence. Early detection is crucial for improving patient prognosis. We therefore performed a meta-analysis to evaluate and compare the sensitivity and specificity of CA19-9 and CA242 in pancreatic cancer. We searched PubMed, EMBASE, and the Cochrane Library for studies that evaluated the diagnostic validity of CA19-9 and CA242 between January 1966 and March 2011. Meta-analysis methods were used to pool sensitivity and specificity and to construct a summary receiver-operating characteristic (SROC) curve. A total of 11 studies that included 2,316 patients who fulfilled all of the inclusion criteria were considered for analysis. The pooled sensitivities for CA242 and CA19-9 were 0.719 (95 % confidence interval [CI] 0.690-0.746) and 0.803 (95 % CI 0.777-0.826), respectively. The pooled specificities of CA242 and CA19-9 were 0.868 (95 % CI 0.849-0.885) and 0.802 (95 % CI 0.780-0.823), respectively. The diagnostic odds ratio (DOR) estimate was significantly higher for CA242 (16.261) than for CA19-9 (15.637). Our meta-analysis showed that CA242 and CA19-9 could play different roles in the diagnosis of pancreatic cancer. Although the sensitivity of CA242 is lower than that of CA19-9, its specificity is greater.
胰腺癌是所有胃肠道癌中预后最差的，死亡率接近发病率。早期发现对于改善患者预后至关重要。因此，我们进行了一项荟萃分析，以评估和比较 CA19-9 和 CA242 在胰腺癌中的敏感性和特异性。我们检索了 PubMed、EMBASE 和 Cochrane 图书馆，以评估 1966 年 1 月至 2011 年 3 月期间 CA19-9 和 CA242 的诊断有效性的研究。采用荟萃分析方法汇总敏感性和特异性，并构建综合受试者工作特征（SROC）曲线。共有 11 项研究符合所有纳入标准，共纳入 2316 例患者进行分析。CA242 和 CA19-9 的合并敏感性分别为 0.719（95%置信区间 0.690-0.746）和 0.803（95%置信区间 0.777-0.826）。CA242 和 CA19-9 的合并特异性分别为 0.868（95%置信区间 0.849-0.885）和 0.802（95%置信区间 0.780-0.823）。CA242 的诊断比值比（DOR）估计值明显高于 CA19-9（16.261 对 15.637）。我们的荟萃分析表明，CA242 和 CA19-9 在胰腺癌的诊断中可能发挥不同的作用。尽管 CA242 的敏感性低于 CA19-9，但特异性更高。
