人 T 滤泡辅助细胞：发育与亚群。

Human T follicular helper cells: development and subsets.

机构信息

Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA.

出版信息

Adv Exp Med Biol. 2013;785:87-94. doi: 10.1007/978-1-4614-6217-0_10.

Abstract

Antibody response constitutes one of the key immune protection mechanisms. T follicular helper (Tfh) cells represent the major CD4⁺ T cell subset that provides help to B cells to induce antibody response. How Tfh cells develop and how Tfh cells or their associated subsets regulate antibody response in humans remains largely unknown. In this review, we will summarize the recent discoveries on the biology of Tfh cells, with a particular focus on human Tfh cells.

摘要

抗体反应构成了关键的免疫保护机制之一。滤泡辅助性 T 细胞（Tfh）代表了主要的 CD4⁺T 细胞亚群，为 B 细胞提供帮助以诱导抗体反应。Tfh 细胞如何发育以及 Tfh 细胞或其相关亚群如何调节人类的抗体反应在很大程度上仍然未知。在这篇综述中，我们将总结 Tfh 细胞生物学的最新发现，特别关注人类 Tfh 细胞。