促红细胞生成素的体内血管生成活性。

In vivo angiogenic activity of erythropoietin.

作者信息

Ribatti Domenico

机构信息

Department of Basic Medical Sciences, University of Bari Medical School, Bari, Italy.

出版信息

Methods Mol Biol. 2013;982:227-35. doi: 10.1007/978-1-62703-308-4_15.

DOI:10.1007/978-1-62703-308-4_15

PMID:23456873

Abstract

The role of erythropoietin (Epo) has been demonstrated in tissues outside the hematopoietic system, including the cardiovascular system, where Epo promotes various effects in endothelial cells. Here, we have demonstrated the angiogenic capacity of recombinant human Epo (rhuEpo) in vivo, by means of the chick embryo chorioallantoic membrane (CAM) assay, a well-established in vivo assay to study angiogenesis and antiangiogenesis.

摘要

促红细胞生成素（Epo）在造血系统以外的组织中的作用已得到证实，包括心血管系统，Epo在该系统中对内皮细胞具有多种作用。在此，我们通过鸡胚绒毛尿囊膜（CAM）试验，一种成熟的用于研究血管生成和抗血管生成的体内试验，证明了重组人促红细胞生成素（rhuEpo）在体内的血管生成能力。