小鼠中的光感受器退化：腺相关病毒载体介导的促红细胞生成素递送
Photoreceptor degeneration in mice: adeno-associated viral vector-mediated delivery of erythropoietin.
作者信息
Colella Pasqualina, Auricchio Alberto
机构信息
Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
出版信息
Methods Mol Biol. 2013;982:237-63. doi: 10.1007/978-1-62703-308-4_16.
PMID:23456874
Abstract
The exogenous delivery of erythropoietin (EPO) and EPO derivatives (EPO-Ds) represents a valuable strategy to protect the retina from degeneration. In this chapter we describe a method to deliver EPO and the EPO derivative S100E in the light-damage model of induced retinal degeneration using adeno--associated viral (AAV) vectors and to evaluate the functional and morphological protection of the retina from light damage.
摘要
外源性递送促红细胞生成素（EPO）及其衍生物（EPO-Ds）是保护视网膜免于退化的一种有价值的策略。在本章中，我们描述了一种在诱导性视网膜变性的光损伤模型中，使用腺相关病毒（AAV）载体递送EPO和EPO衍生物S100E的方法，并评估视网膜免受光损伤的功能和形态学保护作用。
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