在正常的人体大脑动脉中寻找水痘带状疱疹病毒和单纯疱疹病毒-1。
Search for varicella zoster virus and herpes simplex virus-1 in normal human cerebral arteries.
机构信息
Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO 80045, USA.
出版信息
J Neurovirol. 2013 Apr;19(2):181-5. doi: 10.1007/s13365-013-0155-0. Epub 2013 Mar 1.
Abstract
Virological confirmation of varicella zoster virus (VZV) vasculopathy is provided by presence of virus in the cerebral arteries, frequently associated with inflammation. Yet, cerebral arteries from normal subjects have never been studied for VZV DNA or antigen. We analyzed 63 human cerebral arteries from 45 subjects for VZV DNA and antigen, control herpes simplex virus (HSV)-1 DNA and antigen, and leukocyte-specific CD45 antigen. No cerebral arteries contained VZV or HSV-1 DNA or antigen; eight arteries from seven subjects contained leukocytes expressing CD45. Thus, the presence of VZV antigen in cerebral arteries of patients with stroke is likely to be clinically significant.
摘要
水痘带状疱疹病毒（VZV）血管病变的病毒学确认是通过病毒在大脑动脉中的存在提供的，通常与炎症有关。然而，从未研究过正常受试者的大脑动脉中是否存在 VZV DNA 或抗原。我们分析了来自 45 名受试者的 63 个人类大脑动脉，以检测 VZV DNA 和抗原、对照单纯疱疹病毒（HSV）-1 DNA 和抗原以及白细胞特异性 CD45 抗原。没有大脑动脉含有 VZV 或 HSV-1 DNA 或抗原；七名受试者的八根动脉含有表达 CD45 的白细胞。因此，中风患者大脑动脉中存在 VZV 抗原可能具有临床意义。
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