INSERM, UMR 1033, Lyon, France.
PLoS One. 2013;8(2):e55232. doi: 10.1371/journal.pone.0055232. Epub 2013 Feb 15.
Previous studies have shown that microdamage accumulates in bone as a result of physiological loading and occurs naturally in human trabecular bone. The purpose of this study was to determine the factors associated with pre-existing microdamage in human vertebral trabecular bone, namely age, architecture, hardness, mineral and organic matrix. Trabecular bone cores were collected from human L2 vertebrae (n = 53) from donors 54-95 years of age (22 men and 30 women, 1 unknown) and previous cited parameters were evaluated. Collagen cross-link content (PYD, DPD, PEN and % of collagen) was measured on surrounding trabecular bone. We found that determinants of microdamage were mostly the age of donors, architecture, mineral characteristics and mature enzymatic cross-links. Moreover, linear microcracks were mostly associated with the bone matrix characteristics whereas diffuse damage was associated with architecture. We conclude that linear and diffuse types of microdamage seemed to have different determinants, with age being critical for both types.
先前的研究表明，微损伤是由于生理负荷而在骨中累积的，并且在人类小梁骨中自然发生。本研究的目的是确定与人类椎骨小梁骨中预先存在的微损伤相关的因素，即年龄、结构、硬度、矿物质和有机基质。从小梁骨核心中收集了来自人类 L2 椎骨（n=53）的供体，年龄为 54-95 岁（22 名男性和 30 名女性，1 名未知），并评估了以前引用的参数。在周围小梁骨上测量了胶原交联含量（PYD、DPD、PEN 和胶原的%）。我们发现，微损伤的决定因素主要是供体的年龄、结构、矿物质特征和成熟的酶交联。此外，线性微裂纹主要与骨基质特征相关，而弥散性损伤与结构相关。我们得出结论，线性和弥散性微损伤类型似乎有不同的决定因素，年龄对两种类型都很关键。
