Alliot J
Laboratoire de Psychophysiologie, Université Blaise Pascal, Aubiere, France.
Pharmacol Biochem Behav. 1990 Apr;35(4):981-7. doi: 10.1016/0091-3057(90)90388-x.
The effects of subcutaneous administration of vasopressin on spontaneous black-white choice were investigated to determine whether they could account for modifications of performances during learning. First, pretrial injections of 0.2 microgram of lysine-vasopressin (LVP) were given to rats fed ad lib submitted after the last injection to ten consecutive choices in the T-maze. Rats received one or five injections and were tested after either 30 minutes or 24 hours. Treatment with LVP reduced natural photophobia and modified the activity. A more striking effect was observed after one injection and with an injection-test interval of 30 min. Second, the influence of repeated injections of LVP on free choices was studied in food-motivated rats. The effect of repeated injections was marked, suggesting greater sensitivity to treatment in such rats. Third, we compared the action of posttrial administration of the peptide on the behavior of food-restricted rats submitted to appetitive learning in the T-maze, or to free choices. The treatment slightly disturbed the learning of the white arm and altered the preference for black in free choices condition. The two actions were different, showing that the effect on spontaneous behavior cannot account for the effect on learning.
研究了皮下注射血管加压素对自发黑白选择的影响，以确定其是否能解释学习过程中行为表现的改变。首先，对自由进食的大鼠预先注射0.2微克赖氨酸血管加压素（LVP），在最后一次注射后将其放入T型迷宫中连续进行十次黑白选择。大鼠接受一次或五次注射，并在注射后30分钟或24小时进行测试。LVP处理降低了大鼠的天然畏光性并改变了其活动。单次注射且注射-测试间隔为30分钟后观察到更显著的效果。其次，研究了重复注射LVP对以食物为动机的大鼠自由选择的影响。重复注射的效果显著，表明此类大鼠对该处理更为敏感。第三，我们比较了在T型迷宫中接受食欲性学习或自由选择的食物限制大鼠，在试验后给予该肽对其行为的影响。该处理轻微干扰了对白色臂的学习，并在自由选择条件下改变了对黑色的偏好。这两种作用不同，表明对自发行为的影响不能解释对学习的影响。
