Alliot J, Alexinsky T
Physiol Behav. 1982 Mar;28(3):525-30. doi: 10.1016/0031-9384(82)90150-0.
Sixty male rats, maintained on 23-hr food deprivation were trained on two types of appetitive tasks: bar pressure responding under a CRF schedule, and under a differentially reinforced (light+, dark-) schedule. Performance of rats treated with lysing vasopressin, injected immediately after each training session, was compared to that of control animals injected with saline. In the CRF stage, treated animals reached learning criterion significantly later than did control rats, and made significantly fewer bar presses. During acquisition and extinction of a light-dark discrimination, learning and retention were not altered by vasopressin, though the number of bar presses was significantly decreased, and a differential effect was found according to previous CRF performance. The results are discussed considering the hypothesis of a facilitatory effect of vasopressin on memory processes.
六十只雄性大鼠，先禁食23小时，然后对它们进行两种类型的奖励任务训练：在连续强化（CRF）程序下进行压杆反应，以及在差别强化（亮灯+，熄灯-）程序下进行压杆反应。每次训练后立即注射溶解的加压素的大鼠的表现，与注射生理盐水的对照动物的表现进行比较。在CRF阶段，接受治疗的动物比对照大鼠显著更晚达到学习标准，并且压杆次数显著更少。在明暗辨别学习的获得和消退过程中，加压素并未改变学习和记忆，但压杆次数显著减少，并且根据先前的CRF表现发现了差异效应。考虑到加压素对记忆过程有促进作用这一假设，对结果进行了讨论。
