Erokhin V V, Lepekha L N, Erokhina M V, Bocharova I V, Kurynina A V, Onishchenko G E
Vestn Ross Akad Med Nauk. 2012(11):22-8.
Pulmonary surfactant is necessary component for maintenance of high level of phagocytic activity of alveolar macrophages. Tuberculosis inflammation reduces the production of surfactant by type II cells and phagocytic activity of alveolar macrophages. The effects of exogenous pulmonary surfactant on the ultrastructural changes of various subpopulations of alveolar macrophages were studied by TEM-method. For investigations the bronchial alveolar lavage fluid from guinea pigs infected of M. tuberculosis and treated by isoniatid or isoniazid + exogenous pulmonary surfactant were used. It was shown that isoniazid + exogenous pulmonary surfactant normalizes the heterogeneous population of alveolar macrophages providing stimulating effects on their maturation and phagocytic activity more effectively than isoniazid therapy.
肺表面活性物质是维持肺泡巨噬细胞高水平吞噬活性所必需的成分。结核炎症会降低II型细胞表面活性物质的产生以及肺泡巨噬细胞的吞噬活性。通过透射电镜法研究了外源性肺表面活性物质对肺泡巨噬细胞不同亚群超微结构变化的影响。为进行研究，使用了来自感染结核分枝杆菌并用异烟肼或异烟肼+外源性肺表面活性物质治疗的豚鼠的支气管肺泡灌洗液。结果表明，异烟肼+外源性肺表面活性物质可使肺泡巨噬细胞的异质性群体恢复正常，比异烟肼疗法更有效地刺激其成熟和吞噬活性。
