Lepekha L N, Aleksandrova E A, Evgushchenko G V, Makar'iants N N, Lovacheva O V
Vestn Ross Akad Med Nauk. 2012(11):34-8.
Application of complex of modern cytologic methods of research bronchoalveolar lavage allowed to allocate most characteristics of development of lymphocytic and macrophagic reaction of bronchial tree in different course of exogenous allergic alveolitis. The most indicative in assessment of origin of exogenous allergic alveolitis development is the characteristics of macrophagic population. In acute course of exogenous allergic alveolitis the considerable number of young activated and non-activated macrophages, increased number of mature phagocytes is observed. Even more significant increase of phagocytic macrophages is observed at dissemination which is primarily is connected with participation of these cells in lymphocytic apoptosis which takes place in high percentage of lymphocytes (up to 49%). Increased number of mature phagocytes is observed at chronic course of exogenous allergic alveolitis that is an important diagnostic pattern of this option of development of exogenous allergic alveolitis in association with the lowest T-helpers/T-supressors index.
应用现代细胞研究方法对支气管肺泡灌洗进行综合分析，能够明确不同病程的外源性过敏性肺泡炎中支气管树淋巴细胞和巨噬细胞反应发展的最典型特征。评估外源性过敏性肺泡炎发病根源时，最具指示性的是巨噬细胞群体的特征。在外源性过敏性肺泡炎的急性病程中，可观察到大量年轻的活化和未活化巨噬细胞，成熟吞噬细胞数量增加。在疾病播散时，吞噬性巨噬细胞数量增加更为显著，这主要与这些细胞参与淋巴细胞凋亡有关，在高比例淋巴细胞（高达49%）中发生淋巴细胞凋亡。在外源性过敏性肺泡炎的慢性病程中观察到成熟吞噬细胞数量增加，这是外源性过敏性肺泡炎这种发展形式的重要诊断特征，同时伴有最低的辅助性T细胞/抑制性T细胞指数。
