Dermatology Department, Shanghai First People's Hospital, Shanghai, China.
Photodermatol Photoimmunol Photomed. 2013 Apr;29(2):90-6. doi: 10.1111/phpp.12031.
The success rates of conventional treatments to acne vulgaris are limited because of intolerance and resistance. Photodynamic therapy with topical 5-aminolevulinic acid (ALA) and red light has been introduced. However, the side effects especially pigmentation are common.
To study the efficacy and safety of ALA-photodynamic therapy (PDT) with 420-950 nm intense pulsed light (IPL) in Chinese patients with acne vulgaris.
Forty-one patients with moderate to severe facial acne were randomly assigned to ALA-IPL-PDT group and IPL group. Ten percent topical ALA was applied to patients in the ALA-IPL-PDT group, while placebos were applied to patients in the IPL group. After 1 h occlusion, all patients were illuminated with 420-950 nm IPL. The patients in both groups had four treatment sessions with 1-week intervals. One week after each treatment and 4, 8, and 12 weeks after four sessions, acne lesion counts and adverse events were observed.
Twelve weeks after treatments, mean reductions of global lesion counts of ALA-IPL-PDT group and IPL group were 75.2% and 51.0%, respectively. Mean reductions of inflammatory and non-inflammatory lesion counts in ALA-IPL-PDT group were (83.6 ± 4.1)% and (57.5 ± 6.8)%, respectively. No severe adverse events were observed.
ALA-IPL-PDT is an effective treatment for moderate to severe acne vulgaris, and side effects are mild and reversible.
由于不耐受和耐药性，寻常痤疮的常规治疗成功率有限。已经引入了局部 5-氨基酮戊酸（ALA）和红光的光动力疗法（PDT）。然而，常见的副作用，特别是色素沉着。
研究 420-950nm 强脉冲光（IPL）ALA 光动力疗法（PDT）在中国寻常痤疮患者中的疗效和安全性。
将 41 例中重度面部痤疮患者随机分为 ALA-IPL-PDT 组和 IPL 组。ALA-IPL-PDT 组患者外用 10%ALA，IPL 组患者外用安慰剂。ALA 组患者应用 1h 后，用 420-950nm IPL 照射所有患者。两组患者均接受 4 次治疗，间隔 1 周。每次治疗后 1 周及 4、8、12 周观察痤疮皮损计数和不良反应。
治疗 12 周后，ALA-IPL-PDT 组和 IPL 组的总皮损计数平均减少分别为 75.2%和 51.0%。ALA-IPL-PDT 组炎性和非炎性皮损计数的平均减少分别为（83.6±4.1）%和（57.5±6.8）%。未观察到严重不良事件。
ALA-IPL-PDT 是治疗中重度寻常痤疮的有效方法，副作用轻微且可逆。
