Chang Qihang, Liu Xiaojing, Wang Peiru, Yang Yutong, Zhang Linglin, Wang Bo, Wang Xiuli
Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, 1278 Baode Road, Shanghai 200092, P R China.
Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, 1278 Baode Road, Shanghai 200092, P R China.
Photodiagnosis Photodyn Ther. 2024 Apr;46:103999. doi: 10.1016/j.pdpdt.2024.103999. Epub 2024 Feb 7.
High recurrence rate of mild-to-moderate acne vulgaris following traditional therapy poses a significant challenge. 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) with intense pulsed light (IPL) has emerged as a promising intervention.
This study aimed to evaluate the efficacy and safety of IPL-PDT for the treatment of mild-to-moderate acne vulgaris.
In this prospective, self-controlled study, eligible patients aged from 18 to 45 years old with Pillsbury grade Ⅰ-III facial acne were included. Patients were treated with three sessions of IPL-PDT at three-week interval, with follow-ups at 3 weeks and 2 months after the final treatment.
A total of 31 patients were enrolled. At 3 weeks post-treatment, the mean count of acne lesions decreased significantly (P < 0.001), with 87.1 % of patients achieving treatment success (defined as ≥ 75 % clearance rate of acne lesions). Recurrence rate at 2-month follow-up was 9.68 %. No severe adverse reactions were observed.
This study is a single-center, self-controlled study. Multi-center study designed as randomize controlled trials involving a larger patient cohort is necessary.
IPL-PDT is a promising therapy for mild-to-moderate acne vulgaris, exhibiting high efficacy, minimal adverse effects, and a low recurrence rate.
传统疗法后轻度至中度寻常痤疮的高复发率构成了重大挑战。5-氨基酮戊酸光动力疗法（ALA-PDT）联合强脉冲光（IPL）已成为一种有前景的干预措施。
本研究旨在评估IPL-PDT治疗轻度至中度寻常痤疮的疗效和安全性。
在这项前瞻性、自身对照研究中，纳入了年龄在18至45岁、患有Pillsbury Ⅰ-III级面部痤疮的符合条件的患者。患者接受3次IPL-PDT治疗，间隔3周，在最后一次治疗后3周和2个月进行随访。
共纳入31例患者。治疗后3周，痤疮皮损平均计数显著下降（P < 0.001），87.1%的患者治疗成功（定义为痤疮皮损清除率≥75%）。2个月随访时的复发率为9.68%。未观察到严重不良反应。
本研究是一项单中心、自身对照研究。有必要开展多中心随机对照试验设计的研究，纳入更大的患者队列。
IPL-PDT是一种治疗轻度至中度寻常痤疮的有前景的疗法，具有疗效高、不良反应少和复发率低的特点。
