Vanderbilt University Medical Center, Nashville, TN, USA.
Photodermatol Photoimmunol Photomed. 2013 Apr;29(2):106-8. doi: 10.1111/phpp.12032.
Porphyria cutanea tarda (PCT) is a disease caused by a deficiency of the fifth enzyme of the heme biosynthetic pathway in the liver that manifests in the skin as blistering and fragility of predominantly sun-exposed skin. It occurs in individuals with environmental and/or genetic risk factors such as estrogen use, hepatitis C infection and hemochromatosis gene mutations. This report highlights a case of PCT which manifested in an individual with non-alcoholic fatty liver disease (non-alcoholic steatohepatitis; NASH). We propose that NASH may have been a contributing factor for the development of PCT in our patient.
迟发性皮肤卟啉病（PCT）是一种由肝脏中血红素生物合成途径的第五种酶缺乏引起的疾病，主要表现为暴露于阳光的皮肤起泡和脆弱。它发生在具有环境和/或遗传危险因素的个体中，如雌激素使用、丙型肝炎感染和血色素沉着症基因突变。本报告强调了一例 PCT 病例，该病例发生在非酒精性脂肪性肝病（非酒精性脂肪性肝炎；NASH）个体中。我们提出，NASH 可能是导致我们患者发生 PCT 的一个因素。
