INSERM U1092, Université de Limoges, Faculté de Médecine, Limoges, France.
Clin Microbiol Infect. 2013 Jul;19(7):E306-8. doi: 10.1111/1469-0691.12186. Epub 2013 Mar 4.
Hospital effluents are involved in dissemination of antibiotic-resistant integrons. We describe here a new class 3 integron, In3-5, detected in an Enterobacter cloacae isolate retrieved from a random French hospital effluent sample collected in 2009. In3-5 carries two gene cassettes: the new blaOXA -256 and an aac(6')-Ib variant, respectively conferring resistance to β-lactams and aminoglycosides. In3-5 is located on an IncQ-like backbone plasmid. Class 3 integrons could thus be involved in the dissemination of antibiotic resistance in both clinical settings and the environment, and could participate in the exchange of antibiotic-resistance genes between these two ecosystems.
医院污水与抗生素耐药整合子的传播有关。我们在此描述了一种新的 3 类整合子，In3-5，该整合子存在于 2009 年从法国某家随机医院污水样本中分离出的阴沟肠杆菌中。In3-5 携带两个基因盒：新型 blaOXA-256 和 aac(6')-Ib 变体，分别赋予对β-内酰胺类和氨基糖苷类抗生素的耐药性。In3-5 位于 IncQ 样的主质粒上。因此，3 类整合子可能参与了临床环境中抗生素耐药性的传播，并可能在这两个生态系统之间交换抗生素耐药基因。
