Zebeli Qendrim, Beitz Donald C, Bradford Barry J, Dunn Suzanna M, Ametaj Burim N
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada,
Vet Clin Pathol. 2013 Mar;42(1):70-7. doi: 10.1111/vcp.12022.
Milk fever, a metabolic disease of dairy cattle, is associated with perturbations of calcium homeostasis, the pathogenesis of which is not yet completely understood.
The aim of this study was to investigate plasma concentrations of calcitonin gene-related peptide and selected minerals and metabolites in periparturient cows with and without milk fever.
Plasma concentrations of calcitonin gene-related peptide, as well as calcium, phosphate, magnesium, iron, glucose, lactate, and cortisol, were determined in multiple plasma samples from Jersey cows with and without spontaneous milk fever.
Cows affected by milk fever (n = 5) had lower concentrations of calcitonin gene-related peptide (P = .038) and inorganic phosphate (P < .001) in plasma than did the controls (n = 5). Also, these cows tended to have lower calcium concentrations (P = .071). Magnesium, iron, lactate, glucose, and cortisol concentrations were comparable between both groups of cows (P > .10). Around the day of calving, plasma concentrations of lactate, glucose, and cortisol increased and the concentration of iron decreased in all cows (P ≤ .01).
Despite the limited number of cows evaluated, this report is the first to indicate lowered concentrations of calcitonin gene-related peptide as part of the metabolic changes during milk fever in cows. Further work with a larger cohort of animals is warranted to understand the precise role of calcitonin gene-related peptide and the potential associations with disturbances in plasma minerals typically observed during milk fever.
乳热是奶牛的一种代谢性疾病，与钙稳态紊乱有关，其发病机制尚未完全明确。
本研究旨在调查患乳热和未患乳热的围产期奶牛血浆中降钙素基因相关肽及选定矿物质和代谢物的浓度。
测定了患自发性乳热和未患自发性乳热的泽西奶牛多个血浆样本中降钙素基因相关肽以及钙、磷、镁、铁、葡萄糖、乳酸和皮质醇的血浆浓度。
患乳热的奶牛（n = 5）血浆中降钙素基因相关肽浓度（P = .038）和无机磷浓度（P < .001）低于对照组（n = 5）。此外，这些奶牛的钙浓度也有降低趋势（P = .071）。两组奶牛的镁、铁、乳酸、葡萄糖和皮质醇浓度相当（P > .10）。在产犊日前后，所有奶牛的乳酸、葡萄糖和皮质醇血浆浓度均升高，铁浓度降低（P ≤ .01）。
尽管评估的奶牛数量有限，但本报告首次指出降钙素基因相关肽浓度降低是奶牛乳热期间代谢变化的一部分。有必要对更多动物进行进一步研究，以了解降钙素基因相关肽的确切作用以及与乳热期间通常观察到的血浆矿物质紊乱的潜在关联。
