INSERM, UMR912 (SESSTIM), 13006, Marseille, France.
Expert Rev Anti Infect Ther. 2013 Mar;11(3):239-50. doi: 10.1586/eri.13.8.
Antiretroviral therapy for the treatment of HIV infection requires high levels of adherence to both maintain plasma HIV RNA at undetectable levels and prevent the emergence of drug resistance. As adherence to treatment is a major criterion for the evaluation of therapeutic outcomes, randomized clinical trials (RCTs) conducted among HIV-infected patients commonly include an assessment of adherence. However, there is still no gold-standard tool for assessing adherence behaviors in HIV RCTs. The methods currently used to collect and analyze adherence data are varied, which makes the comparison of results between studies difficult. The scope of this article is to review and discuss the range of adherence measures currently used in RCTs conducted among HIV-infected adults.
抗逆转录病毒疗法治疗 HIV 感染需要高度的依从性，以维持血浆 HIV RNA 处于不可检测水平并预防耐药性的出现。由于治疗依从性是评估治疗效果的主要标准，因此在 HIV 感染者中进行的随机临床试验（RCT）通常包括对依从性的评估。然而，目前仍然没有评估 HIV RCT 中依从行为的金标准工具。目前用于收集和分析依从性数据的方法多种多样，这使得研究之间的结果比较变得困难。本文的范围是回顾和讨论目前在 HIV 成年感染者中进行的 RCT 中使用的各种依从性测量方法。
