Fusco Francesco Maria, Sangiovanni Nadia, Papa Nunzia, Cuomo Nunzia, Tambaro Orsola, Iodice Valentina, Bruner Vincenzo, Carleo Maria Aurora, Rizzo Viviana, Palmiero Giulia, Di Lorenzo Mariana, Spatarella Micaela, Viglietti Rosaria, Sangiovanni Vincenzo, Esposito Vincenzo
"D. Cotugno" Hospital, AOS dei Colli, Naples, Italy.
Infez Med. 2022 Sep 1;30(3):440-445. doi: 10.53854/liim-3003-13. eCollection 2022.
A gold-standard for the measurement of adherence to antiretroviral therapy (ART) is lacking. Aim of this study is to verify the feasibility of a package-refill-based measurement of ART at "D. Cotugno" hospital, Naples, Italy, and the factors associated to adherence.
In the period January 2018-August 2020, we calculated the package-refill as the ratio between ART-packages actually withdrawn, and the ART packages needed to regularly take ART. Adherence was associated, trough a univariate e multivariate logistic regression, to demographical, behavioural and clinical factors.
1140 HIV+ subjects were included. At univariate logistic regression inadequate package-refill-based adherence is associated with HIV-RNA higher than 50 copies/mmL (OR 3.77-IC95% 2.76-5.13) and with HIVRNA higher than 200 copies/mmL (OR 3.98-IC95% 2.69-5.90). Being not-Italian and Injective-drug-user are associated with low adherence, having HIV/AIDS for more than 8 years is associated with better adherence.
Package-refill is a suitable method for measuring adherence and is associated with the condition of viral failure.
目前缺乏衡量抗逆转录病毒疗法（ART）依从性的金标准。本研究的目的是验证在意大利那不勒斯的“D. Cotugno”医院基于药品包装再填充来衡量ART依从性的可行性以及与依从性相关的因素。
在2018年1月至2020年8月期间，我们将药品包装再填充计算为实际领取的ART药品包装数量与定期服用ART所需的药品包装数量之比。通过单变量和多变量逻辑回归分析，将依从性与人口统计学、行为学和临床因素相关联。
共纳入1140名HIV阳性受试者。在单变量逻辑回归分析中，基于药品包装再填充的依从性不足与HIV-RNA高于50拷贝/毫升（比值比3.77 - 95%置信区间2.76 - 5.13）以及HIV-RNA高于200拷贝/毫升（比值比3.98 - 95%置信区间2.69 - 5.90）相关。非意大利籍和注射吸毒者与低依从性相关，感染HIV/AIDS超过8年与更好的依从性相关。
药品包装再填充是一种衡量依从性的合适方法，并且与病毒治疗失败情况相关。
