Souayah N, Saadeh P, Krivitskaya N, Sander H W
Department of Neurology, New Jersey Medical School, 90 Bergen Street, DOC 8100, Newark, NJ 07103, USA.
J Vasc Interv Neurol. 2013 Feb;5(2):1-3.
To study the effect of the cutaneous silent period (CSP) on spontaneous muscle activity occurring after an upper motor injury from stroke, with a goal of developing an insight into the origin of the pathological activity.
A patient with an acute right centrum semiovale ischemic stroke had left hemiparesis. Fibrillation potentials and positive sharp waves were recorded in several left arm muscles. CSP silent period studies were performed in both arms.
The CSP inhibited the volitional activity in the unaffected right arm. In the plegic left arm, fibrillation potentials and positive sharp waves persisted during the time period during which the CSP would have been expected, based upon the right-sided studies.
Spontaneous activity after a cerebrovascular accident was resistant to inhibition from CSP. These findings suggest that the localization of the origin of the spontaneous activity is distal to the upper motor neuron. A confirmatory study with more patients and in a variety of stroke subtypes would strengthen this conclusion.
研究皮层静息期（CSP）对中风所致上运动神经元损伤后出现的自发肌肉活动的影响，旨在深入了解病理性活动的起源。
一名急性右半卵圆中心缺血性中风患者出现左侧偏瘫。在左侧多块手臂肌肉中记录到纤颤电位和正锐波。对双侧手臂进行了CSP静息期研究。
CSP抑制了未受影响的右侧手臂的随意活动。在瘫痪的左侧手臂，根据右侧研究结果，在预期出现CSP的时间段内，纤颤电位和正锐波持续存在。
脑血管意外后的自发活动对CSP的抑制具有抗性。这些发现表明，自发活动起源的定位在上运动神经元的远端。纳入更多患者并针对多种中风亚型进行的验证性研究将强化这一结论。
