Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France.
J Nutr Health Aging. 2013 Mar;17(3):235-9. doi: 10.1007/s12603-012-0394-4.
The interpretation of the increase in stride-to-stride variability of stride time (STV) regarding the evolution of cognitive deficits across the dementia spectrum is matter of debate.
The aim of this study was to compare STV at usual and fast-pace walking speeds of MCI patients with that of cognitively healthy individuals (CHI) and Alzheimer's disease (AD) patients with mild dementia, while considering the effects of potential confounders.
STV while walking at usual and fast-pace walking speeds was recorded with the GAITRite® system from 116 older adults (mean age 75.6±6.5 years; 55.2% female) divided into 3 groups according to their cognitive status (44 CHI, 39 MCI patients and 33 AD patients with mild dementia).
The full adjusted multiple linear regression models showed that high STV was associated with slow gait speed at usual-pace walking speed (P=0.002) and with the MCI status at fast-pace walking speed (P=0.015).
High STV at fast-pace walking speed was a specific gait disturbance of MCI patients in the sample of studied participants, and thus could be used in the future as a specific biomarker of MCI patients.
关于认知障碍在痴呆谱中的演变，步长时间（STV）逐拍变化的解释是有争议的。
本研究旨在比较认知障碍患者（MCI）和轻度痴呆的阿尔茨海默病（AD）患者在常速和快速步行速度下的 STV，同时考虑潜在混杂因素的影响。
使用 GAITRite®系统记录了 116 名老年人（平均年龄 75.6±6.5 岁；55.2%为女性）在常速和快速步行速度下的 STV，这些老年人根据其认知状态分为 3 组（44 名认知健康者（CHI）、39 名 MCI 患者和 33 名轻度痴呆的 AD 患者）。
完全调整后的多元线性回归模型显示，高 STV 与常速步行速度下的慢步速相关（P=0.002），与快速步行速度下的 MCI 状态相关（P=0.015）。
在研究参与者的样本中，快速步行速度下的高 STV 是 MCI 患者特定的步态障碍，因此将来可以用作 MCI 患者的特定生物标志物。
