遗忘型轻度认知障碍和运动认知风险综合征中不同的脑萎缩模式。
Distinct Patterns of Brain Atrophy in Amnestic Mild Cognitive Impairment and Motoric Cognitive Risk Syndromes.
作者信息
Nagamalla Vineela, Verghese Joe, Ayers Emmeline, Barzilai Nir, Beauchet Olivier, Lipton Richard B, Shimada Hiroyuki, Srikanth Velandai K, Blumen Helena M
机构信息
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
出版信息
Neurodegener Dis. 2024;24(3-4):117-128. doi: 10.1159/000540512. Epub 2024 Aug 5.
INTRODUCTION
Motoric cognitive risk (MCR) and amnestic mild cognitive impairment (aMCI) syndromes are each reliable predictors of incident Alzheimer's disease (AD), but MCR may be a stronger predictor of vascular dementia than AD. This study contrasted cortical and hippocampal atrophy patterns in MCR and aMCI.
METHODS
Cross-sectional data from 733 older adults without dementia or disability (M age = 73.6; 45% women) in the multicountry MCR consortium were examined. MCR was defined as presence of slow gait and cognitive concerns. Amnestic MCI was defined as poor episodic memory performance and cognitive concerns. Cortical thickness and hippocampal volumes were quantified from structural MRIs. Multivariate and univariate general linear models were used to examine associations between cortical thickness and hippocampal volume in MCR and aMCI, adjusting for age, sex, education, total intracranial volume, white matter lesions, and study site.
RESULTS
The prevalence of MCR and aMCI was 7.64% and 12.96%, respectively. MCR was associated with widespread cortical atrophy, including prefrontal, insular, cingulate, motor, parietal, and temporal atrophy. aMCI was associated with hippocampal atrophy.
CONCLUSION
Distinct patterns of atrophy were associated with MCR and aMCI. A distributed pattern of cortical atrophy - that is more consistent with VaD or mixed dementia- was observed in MCR. A more restricted pattern of atrophy - that is more consistent with AD - was observed in aMCI. The biological underpinnings of MCR and aMCI likely differ and may require tailored interventions.
INTRODUCTION
Motoric cognitive risk (MCR) and amnestic mild cognitive impairment (aMCI) syndromes are each reliable predictors of incident Alzheimer's disease (AD), but MCR may be a stronger predictor of vascular dementia than AD. This study contrasted cortical and hippocampal atrophy patterns in MCR and aMCI.
METHODS
Cross-sectional data from 733 older adults without dementia or disability (M age = 73.6; 45% women) in the multicountry MCR consortium were examined. MCR was defined as presence of slow gait and cognitive concerns. Amnestic MCI was defined as poor episodic memory performance and cognitive concerns. Cortical thickness and hippocampal volumes were quantified from structural MRIs. Multivariate and univariate general linear models were used to examine associations between cortical thickness and hippocampal volume in MCR and aMCI, adjusting for age, sex, education, total intracranial volume, white matter lesions, and study site.
RESULTS
The prevalence of MCR and aMCI was 7.64% and 12.96%, respectively. MCR was associated with widespread cortical atrophy, including prefrontal, insular, cingulate, motor, parietal, and temporal atrophy. aMCI was associated with hippocampal atrophy.
CONCLUSION
Distinct patterns of atrophy were associated with MCR and aMCI. A distributed pattern of cortical atrophy - that is more consistent with VaD or mixed dementia- was observed in MCR. A more restricted pattern of atrophy - that is more consistent with AD - was observed in aMCI. The biological underpinnings of MCR and aMCI likely differ and may require tailored interventions.
引言
运动认知风险（MCR）和遗忘型轻度认知障碍（aMCI）综合征都是新发阿尔茨海默病（AD）的可靠预测指标，但MCR可能是血管性痴呆比AD更强的预测指标。本研究对比了MCR和aMCI患者的皮质和海马萎缩模式。
方法
对多国MCR联盟中733名无痴呆或残疾的老年人（平均年龄=73.6岁；45%为女性）的横断面数据进行了研究。MCR定义为存在步态缓慢和认知问题。遗忘型MCI定义为情景记忆表现差和认知问题。从结构磁共振成像（MRI）中量化皮质厚度和海马体积。使用多变量和单变量一般线性模型来研究MCR和aMCI中皮质厚度与海马体积之间的关联，并对年龄、性别、教育程度、总颅内体积、白质病变和研究地点进行了调整。
结果
MCR和aMCI的患病率分别为7.64%和12.96%。MCR与广泛的皮质萎缩相关，包括前额叶、岛叶、扣带回、运动区、顶叶和颞叶萎缩。aMCI与海马萎缩相关。
结论
MCR和aMCI与不同的萎缩模式相关。在MCR中观察到一种更符合血管性痴呆或混合性痴呆的皮质萎缩分布模式。在aMCI中观察到一种更局限的萎缩模式，更符合AD。MCR和aMCI的生物学基础可能不同，可能需要针对性的干预措施。
引言
运动认知风险（MCR）和遗忘型轻度认知障碍（aMCI）综合征都是新发阿尔茨海默病（AD）的可靠预测指标，但MCR可能是血管性痴呆比AD更强的预测指标。本研究对比了MCR和aMCI患者的皮质和海马萎缩模式。
方法
对多国MCR联盟中733名无痴呆或残疾的老年人（平均年龄=73.6岁；45%为女性）的横断面数据进行了研究。MCR定义为存在步态缓慢和认知问题。遗忘型MCI定义为情景记忆表现差和认知问题。从结构磁共振成像（MRI）中量化皮质厚度和海马体积。使用多变量和单变量一般线性模型来研究MCR和aMCI中皮质厚度与海马体积之间的关联，并对年龄、性别、教育程度、总颅内体积、白质病变和研究地点进行了调整。
结果
MCR和aMCI的患病率分别为7.64%和12.96%。MCR与广泛的皮质萎缩相关，包括前额叶、岛叶、扣带回、运动区、顶叶和颞叶萎缩。aMCI与海马萎缩相关。
结论
MCR和aMCI与不同的萎缩模式相关。在MCR中观察到一种更符合血管性痴呆或混合性痴呆的皮质萎缩分布模式。在aMCI中观察到一种更局限的萎缩模式，更符合AD。MCR和aMCI的生物学基础可能不同，可能需要针对性的干预措施。
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