[Nonenzymatic glycosylation of serum albumin and thymic DNA by food monosugars and their natural metabolites that form in the body].

The nonenzymatic glycosylation of human plasma albumin by glucose, fructose, xylose, glucose-6-P, fructose-6-P, 6-PP was studied in vitro. The most manifest differences in the albumin spectrum (250-390 nm) were observed when fructose-6-P and xylose were used. The use of 3H-glucose and 14C-fructose has shown that there are 2 sites for glucose addition, 4 sites for fructose addition and 1 site to which both glucose and fructose can be bound, but glucose is preferable. Calf thymus DNA has 10 sites to which carbohydrate can be bound: 4 for glucose and 6 for fructose, only.