González-Campo Arántzazu, Amabilino David B
Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus Universitari de Bellaterra, 08193, Cerdanyola del Vallès, Catalonia, Spain.
Top Curr Chem. 2013;333:109-56. doi: 10.1007/128_2012_405.
Interfaces are a most important environment in natural and synthetic chemistries for a wide variety of processes, such as catalysis, recognition, separation, and so on. Naturally occurring systems have evolved to one handedness and the study of interfaces where biomolecules are located is a potentially revealing pursuit with regard to understanding the reasons and importance of stereochemistry in these environments. Equally, the spontaneous resolution of achiral and chiral compounds at interfaces could lead to explanations regarding the emergence of single handedness in proteins and sugars. Also, the attachment of biomolecules to surfaces leads to systems capable of stereoselective processes which may be useful for the applications mentioned above. The review covers systems ranging from small biomolecules studied under ultrapure conditions in vacuum to protein adsorption to surfaces in solution, and the techniques that can be used to study them.
界面是自然化学和合成化学中极为重要的环境，涉及多种过程，如催化、识别、分离等。天然存在的体系已进化为单一手性，研究生物分子所在的界面对于理解这些环境中立体化学的原因和重要性具有潜在的启发性。同样，非手性和手性化合物在界面处的自发拆分可能会解释蛋白质和糖类中单一手性的出现。此外，生物分子与表面的附着会形成能够进行立体选择性过程的体系，这可能对上述应用有用。本综述涵盖了从在超高纯真空条件下研究的小分子生物分子到溶液中蛋白质在表面的吸附等各种体系，以及可用于研究它们的技术。
