Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
J Pathol. 2013 Jul;230(3):241-8. doi: 10.1002/path.4188.
Tumour necrosis factor (TNF) was originally described as a circulating factor that can induce haemorrhagic necrosis of tumours. It is now clear that TNF has many different functions in cancer biology. In addition to causing the death of cancer cells, TNF can activate cancer cell survival and proliferation pathways, trigger inflammatory cell infiltration of tumours and promote angiogenesis and tumour cell migration and invasion. These effects can be explained by the diverse cellular responses TNF can initiate through distinct signal transduction pathways, opening the way for more selective targeting of TNF signalling in cancer therapy.
肿瘤坏死因子（TNF）最初被描述为一种可诱导肿瘤出血坏死的循环因子。现在已经清楚的是，TNF 在癌症生物学中具有许多不同的功能。除了导致癌细胞死亡外，TNF 还可以激活癌细胞的存活和增殖途径，触发肿瘤中炎症细胞的浸润，并促进血管生成和肿瘤细胞的迁移和侵袭。这些作用可以通过 TNF 可以通过不同的信号转导途径启动的多种细胞反应来解释，为在癌症治疗中更有选择性地靶向 TNF 信号通路开辟了道路。
