Abood Ali, Vestergaard Peter
Institute for Medicine and Health Technology, Aalborg University, Aalborg, Denmark.
Dan Med J. 2013 Feb;60(2):A4567.
Primary hyperparathyroidism is a common endocrine disorder with different epidemiological patterns among countries. In Denmark, the incidence of primary hyperparathyroidism was last described in 1999 when it was reported to follow an increasing trend. In the present study, we evaluated trends in the incidence of primary hyperparathyroidism in Denmark up to 2010.
All patients diagnosed with primary hyperparathyroidism from 1977 to 2010 were included. Annual incidence rates were calculated.
The overall incidence was clearly increased at the end of 2010 with an annual rate of 16 per 100,000. Following a cyclic curve, year-to-year incidence rates were fluctuating. During the entire period, the incidence was higher in women than in men. Furthermore, in women above the age of 50 years, a five-fold increase in incidence was observed, while there was no difference in the increase among men above the age of 50 years compared with men under the age of 50 years.
The incidence of primary hyperparathyroidism in Denmark continues its remarkable rise. The overall increase in incidence may be the result of more frequent plasma calcium measurements as well as the prevailing obesity epidemic. The dramatic increase in incidence observed among women over the age of 50 years requires further studies. The causes of the cyclic trend observed are uncertain, as no seasonal variation was seen.
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原发性甲状旁腺功能亢进是一种常见的内分泌疾病，各国的流行病学模式有所不同。在丹麦，原发性甲状旁腺功能亢进的发病率上次描述是在1999年，当时据报道呈上升趋势。在本研究中，我们评估了截至2010年丹麦原发性甲状旁腺功能亢进发病率的趋势。
纳入了1977年至2010年期间所有诊断为原发性甲状旁腺功能亢进的患者。计算年发病率。
到2010年底，总体发病率明显上升，年发病率为每10万人中有16例。发病率呈周期性曲线，逐年波动。在整个时期，女性的发病率高于男性。此外，50岁以上女性的发病率增加了五倍，而50岁以上男性与50岁以下男性相比，发病率增加没有差异。
丹麦原发性甲状旁腺功能亢进的发病率持续显著上升。发病率的总体上升可能是血钙检测更频繁以及普遍存在的肥胖流行的结果。50岁以上女性发病率的急剧上升需要进一步研究。观察到的周期性趋势的原因尚不确定，因为未发现季节性变化。
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