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伴有变应性曲霉菌性鼻窦炎和变应性支气管肺曲霉菌病,且变应性支气管肺曲霉菌病有家族发病情况。

Concomitant allergic Aspergillus sinusitis and allergic bronchopulmonary aspergillosis associated with familial occurrence of allergic bronchopulmonary aspergillosis.

作者信息

Shah A, Khan Z U, Chaturvedi S, Malik G B, Randhawa H S

机构信息

Department of Clinical Research, University of Delhi, India.

出版信息

Ann Allergy. 1990 Jun;64(6):507-12.

PMID:2346236
Abstract

A 24-year-old male, who had nasal symptoms with occasional wheezing was evaluated for consolidation of the right lung which led to the diagnosis of concomitant allergic Aspergillus sinusitis (AAS) and allergic bronchopulmonary aspergillosis (ABPA), a rarely reported association. The patient's mother was a diagnosed case of ABPA. Dramatic relief of nasal and pulmonary symptoms resulted with prednisolone that could not be tapered off completely. No untoward effect of prednisolone was observed on the disease process in a follow-up of 2 years. A high index of suspicion is required for the diagnosis of AAS and family members with history of asthma and/or rhinitis should be investigated for ABPA and/or AAS.

摘要

一名24岁男性,有鼻部症状并偶尔喘息,因右肺实变接受评估,最终诊断为合并变应性曲霉菌性鼻窦炎(AAS)和变应性支气管肺曲霉菌病(ABPA),这是一种罕见的关联情况。患者的母亲被诊断为ABPA。泼尼松龙使鼻部和肺部症状显著缓解,但无法完全减量。在2年的随访中,未观察到泼尼松龙对疾病进程有不良影响。诊断AAS需要高度怀疑,对于有哮喘和/或鼻炎病史的家庭成员,应调查是否患有ABPA和/或AAS。

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