Lacquet L K, Schreinemakers J H
Institut de Chirurgie Thoracique et Cardiaque, Hôpital Universitaire, St-Radboud, Nijmegen.
Ann Chir. 1990;44(2):143-5.
Since explorative thoracotomy and palliative resection do not in effect prolong life expectancy, it is essential to determine the operability of a lung tumour as accurately as possible. Cervical mediastinoscopy has considerably decreased the percentage of explorative thoracotomies. However, the lymph nodes in the periaortic region cannot be reached by cervical mediastinoscopy and these form an important lymph drainage pathway for the left upper lobe. The periaortic lymph nodes can be explored by left parasternal mediastinoscopy. In the present study, we investigated the value of combined cervical and parasternal mediastinoscopy in all patients with clinically operable central lung cancer of the left upper lobe, and in selected patients with a peripheral cancer of the left upper lobe. In the retrospective group, we found metastases at cervical mediastinoscopy in 23.4% of the patients with a tumour or the left lung and in 12.9% of the patients with a tumour of the left upper lobe. In the prospective group, we found metastases at cervical mediastinoscopy, possibly combined with parasternal mediastinoscopy, in 43% of the patients with a tumour of the left lung and in 41.9% of the patients with a tumour of the left upper lobe. All patients with positive mediastinoscopy involving either multiple nodes or an extranodal site, were excluded from operation. The number of explorative thoracotomies dropped in the prospective period and the resectability increased from 80.8% to 92.9% for the left lung and from 79.4% to 96.5% for the left upper lobe. These data indicate the reliability of parasternal mediastinoscopy in the assessment of the operability of left upper lobe lung cancer, in order to avoid unnecessary toracotomies and to avoid palliative resections.
由于探索性开胸手术和姑息性切除术实际上并不能延长预期寿命,因此尽可能准确地确定肺肿瘤的可切除性至关重要。颈部纵隔镜检查已显著降低了探索性开胸手术的比例。然而,颈部纵隔镜检查无法触及主动脉周围区域的淋巴结,而这些淋巴结是左上叶重要的淋巴引流途径。主动脉周围淋巴结可通过左胸骨旁纵隔镜检查进行探查。在本研究中,我们调查了联合颈部和胸骨旁纵隔镜检查在所有临床上可切除的左上叶中央型肺癌患者以及部分左上叶周围型肺癌患者中的价值。在回顾性研究组中,我们发现,在患有左肺肿瘤的患者中,23.4%在颈部纵隔镜检查时发现有转移;在患有左上叶肿瘤的患者中,12.9%在颈部纵隔镜检查时发现有转移。在前瞻性研究组中,我们发现,在患有左肺肿瘤的患者中,43%在颈部纵隔镜检查时发现有转移,可能同时合并胸骨旁纵隔镜检查发现转移;在患有左上叶肿瘤的患者中,41.9%在颈部纵隔镜检查时发现有转移。所有纵隔镜检查阳性的患者,包括涉及多个淋巴结或淋巴结外部位的患者,均被排除在手术之外。在前瞻性研究期间,探索性开胸手术的数量有所下降,左肺的可切除率从80.8%提高到92.9%,左上叶的可切除率从79.4%提高到96.5%。这些数据表明,胸骨旁纵隔镜检查在评估左上叶肺癌可切除性方面具有可靠性,以避免不必要的开胸手术和姑息性切除。