Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Nanoscale. 2013 Apr 7;5(7):2570-88. doi: 10.1039/c3nr33193h.
Due to their ultra-small size, nanoparticles (NPs) have distinct properties compared with the bulk form of the same materials. These properties are rapidly revolutionizing many areas of medicine and technology. NPs are recognized as promising and powerful tools to fight against the human brain diseases such as multiple sclerosis or Alzheimer's disease. In this review, after an introductory part on the nature of protein fibrillation and the existing approaches for its investigations, the effects of NPs on the fibrillation process have been considered. More specifically, the role of biophysicochemical properties of NPs, which define their affinity for protein monomers, unfolded monomers, oligomers, critical nuclei, and other prefibrillar states, together with their influence on protein fibrillation kinetics has been described in detail. In addition, current and possible-future strategies for controlling the desired effect of NPs and their corresponding effects on the conformational changes of the proteins, which have significant roles in the fibrillation process, have been presented.
由于其超小尺寸，纳米颗粒（NPs）与相同材料的块状形式相比具有独特的性质。这些特性正在迅速彻底改变医学和技术的许多领域。NPs 被认为是对抗多发性硬化症或阿尔茨海默病等人类脑部疾病的有前途和强大的工具。在这篇综述中，在介绍蛋白质纤化的性质和现有的研究方法之后，考虑了 NPs 对纤化过程的影响。更具体地说，详细描述了 NPs 的生物物理化学性质在决定其与蛋白质单体、展开单体、寡聚物、临界核和其他前纤丝状状态的亲和力方面的作用，以及它们对蛋白质纤化动力学的影响。此外，还介绍了当前和未来可能的控制 NPs 所需效果的策略，以及它们对在纤化过程中起重要作用的蛋白质构象变化的相应影响。
