Department of Neurosurgery, Cantonal Hospital, 5001, Aarau, Switzerland.
Curr Neurol Neurosci Rep. 2013 Apr;13(4):337. doi: 10.1007/s11910-013-0337-4.
Meningiomas represent the most common primary brain tumor and comprise 3 World Health Organization (WHO) grades, the most frequent being WHO grade I (90%). Surgery is mandatory to establish the diagnosis and to remove the tumor; however, complete resection can be achieved in only <50% of patients. Depending on the extent of resection, tumor location and the WHO grade radiation therapy can be applied. The issue of systemic treatment such as chemotherapy or targeted therapy (eg, somatostatin receptors, antiangiogenic agents) is yet not solved, particularly as current data are derived from small uncontrolled series in patients with long-standing disease and after several pretreatments. A more thorough understanding of molecular genetics, signaling pathways and prognostic factors in meningiomas should lead to the design of studies which stratify according to these factors. These studies have to be conducted in newly diagnosed patients after incomplete resection and in tumors of WHO grade II and III.
脑膜瘤是最常见的原发性脑肿瘤，包括 3 个世界卫生组织 (WHO) 分级，最常见的是 WHO 分级 I（90%）。手术是确定诊断和切除肿瘤的必要手段；然而，只有 <50%的患者可以实现完全切除。根据切除范围、肿瘤位置和 WHO 分级，可应用放疗。化疗或靶向治疗（例如，生长抑素受体、抗血管生成剂）等全身治疗的问题尚未解决，特别是因为目前的数据来自于长期患病且经过多次预处理的患者的小型非对照系列。对脑膜瘤的分子遗传学、信号通路和预后因素有更深入的了解，应有助于设计根据这些因素分层的研究。这些研究必须在不完全切除后的新诊断患者和 WHO 分级 II 和 III 的肿瘤中进行。
