Schneider J S, Moore D H, Sagebiel R W
Permanente Medical Group, San Rafael, Calif.
Arch Dermatol. 1990 Jun;126(6):767-9.
The Lawrence Livermore (Calif) National Laboratory (LLNL) has observed a threefold increase in incidence of cutaneous malignant melanoma (CMM) since 1972. A consultant pathologist reviewed 49 of 50 cases of CMM diagnosed from 1969 to 1984 and reclassified 4 cases; this did not significantly affect the elevated rate. A comparison of the thicknesses of CMM at LLNL from 1976 to 1984 with those from a nearby community histopathology laboratory showed that 74% of the LLNL cases were Clark level I or II, compared with 40% of the comparison laboratory cases. A matched-pair comparison controlling for age, sex, and year of diagnosis showed the LLNL cases were thinner in 58% of the pairs. The median thickness of CMMs at LLNL decreased faster than those from the comparison laboratory.
自1972年以来，位于加利福尼亚州劳伦斯利弗莫尔的国家实验室（LLNL）观察到皮肤恶性黑色素瘤（CMM）的发病率增长了两倍。一位顾问病理学家对1969年至1984年诊断出的50例CMM病例中的49例进行了复查，并重新分类了4例；这并未显著影响升高的发病率。将LLNL在1976年至1984年的CMM厚度与附近社区组织病理学实验室的CMM厚度进行比较，结果显示LLNL病例中有74%为克拉克一级或二级，而对照实验室病例中这一比例为40%。一项对年龄、性别和诊断年份进行控制的配对比较显示，在58%的配对中，LLNL的病例更薄。LLNL的CMM中位厚度比对照实验室的下降得更快。
