Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA.
Curr Top Microbiol Immunol. 2013;369:199-218. doi: 10.1007/978-3-642-27340-7_8.
Hepatitis C Virus (HCV) particles exhibit several unusual properties that are not found in other enveloped RNA viruses, most notably their low buoyant density and interaction with serum lipoproteins. With the advent of systems to grow HCV in cell culture, the molecular basis of HCV particle assembly and release can now be addressed. The process of virus assembly involves protein-protein interactions between viral structural and nonstructural proteins and the coordinated action of host factors. This chapter reviews our current understanding of these interactions and factors.
丙型肝炎病毒（HCV）颗粒表现出几种在其他包膜 RNA 病毒中未发现的异常特性，最显著的是其较低的浮力密度和与血清脂蛋白的相互作用。随着在细胞培养中培养 HCV 的系统的出现，现在可以解决 HCV 颗粒组装和释放的分子基础。病毒组装的过程涉及病毒结构蛋白和非结构蛋白之间的蛋白-蛋白相互作用以及宿主因子的协调作用。本章回顾了我们对这些相互作用和因素的现有认识。
