Department of Orthopedics, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200021, China.
Arch Orthop Trauma Surg. 2013 Jun;133(6):781-8. doi: 10.1007/s00402-013-1711-z. Epub 2013 Mar 5.
To compare the influence of the different osteochondral incongruity grades on the osteochondral repair by the mosaicplasty technique in a goat model.
The acute defects were created in the weight-bearing area of the medial femoral condyle of the goats. Mosaicplasty was done to repair the defects. While implanting the cylindrical osteochondral grafts, different osteochondral sunk, or elevated incongruities were created. The goats were killed 12 weeks after operation to receive gross and histology observation, which was evaluated by the histological grading scale of O'Driscoll et al. The specimens were also taken for transmission electron microscope examination. Two factors analysis of variance and Student-Newman-Kewls test were used to compare the specimen.
Minimal steps, which were less than the thickness of cartilage, possess a capacity for remodeling that can correct initial incongruities while preserving hyaline characteristics. However, the step more than the thickness of cartilage could not be repaired satisfactorily.
The incongruity could have an influence on the repair by the mosaicplasty technique in a goat model. The limited incongruity could be repaired by a vigorous remodeling process.
比较不同等级的软骨下骨不平整对马赛克plasty 技术修复山羊模型软骨下骨缺损的影响。
在山羊股骨内髁负重区制造急性缺损，用马赛克plasty 技术修复缺损。在植入圆柱形软骨下骨移植物时，会造成不同程度的软骨下骨下沉或抬高不平整。术后 12 周处死山羊，进行大体和组织学观察，采用 O'Driscoll 等的组织学分级标准进行评价。还对标本进行透射电镜检查。采用两因素方差分析和 Student-Newman-Kewls 检验对标本进行比较。
小于软骨厚度的微小台阶具有重塑能力，可在保持透明软骨特征的同时纠正初始不平整。然而，大于软骨厚度的台阶则不能得到满意的修复。
软骨下骨不平整会影响马赛克plasty 技术在山羊模型中的修复效果。有限的不平整可以通过活跃的重塑过程得到修复。
