Department of Nutrition and Feeding of Farm Animals, Institute of Animal Science, Přátelství 815, Uhříněves, 104 00, Prague 10, Czech Republic.
Biol Trace Elem Res. 2013 Jun;152(3):343-9. doi: 10.1007/s12011-013-9638-3. Epub 2013 Mar 6.
Pharmacological dietary zinc (Zn) concentrations of 1,000 to 3,000 mg/kg diet from Zn oxide have been found to increase growth in post-weaning pigs. However, results were inconsistent among studies. A frequentist meta-analysis, in which effects were numerically described with standardized effect sizes (Hedges's g), was conducted in order to identify and quantify the responses in average daily gain (ADG), average daily feed intake (ADFI), and gain to feed ratio (G/F) in post-weaning pigs upon dietary Zn supplementation from Zn oxide. The inability of independent continuous variables to explain significant heterogeneity obtained with fixed effect models necessitated the use of random effects models to calculate summary statistics. Dietary Zn supplementation increased (P < 0.05) ADG (mean effect size = 1.086, 95 % confidence intervals = 0.905-1.266, 26 studies, 72 comparisons), ADFI (mean effect size = 0.794, 95 % confidence intervals = 0.616-0.971, 25 studies, 71 comparisons), and G/F (mean effect size = 0.566, 95 % confidence intervals = 0.422-0.710, 24 studies, 70 comparisons). Zinc oxide provided a feasible alternative to in-feed antibiotics to improve growth in post-weaning pigs, and its reduction in diets due to potential environmental pollution will have to be negated by alternative feed additives and management strategies in order to prevent economic losses.
在饲粮中添加 1000 至 3000 毫克/千克氧化锌的锌（Zn）可提高断奶仔猪的生长性能。然而，各研究结果并不一致。本研究采用固定效应模型和随机效应模型对饲粮添加氧化锌的锌源对断奶仔猪平均日增重（ADG）、平均日采食量（ADFI）和料重比（G/F）的影响进行了荟萃分析，以确定和量化其响应。独立连续变量无法解释固定效应模型获得的显著异质性，因此需要使用随机效应模型来计算汇总统计数据。饲粮添加锌可提高（P < 0.05）ADG（平均效应大小 = 1.086，95%置信区间 = 0.905-1.266，26 项研究，72 个比较）、ADFI（平均效应大小 = 0.794，95%置信区间 = 0.616-0.971，25 项研究，71 个比较）和 G/F（平均效应大小 = 0.566，95%置信区间 = 0.422-0.710，24 项研究，70 个比较）。氧化锌可替代饲粮中的抗生素，提高断奶仔猪的生长性能，但由于其潜在的环境污染，饲粮中锌的用量将会减少，因此必须通过替代饲料添加剂和管理策略来抵消这种减少，以防止经济损失。
