Department of Microbiology & Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA.
Future Med Chem. 2013 Mar;5(3):281-9. doi: 10.4155/fmc.12.215.
TGF-β was originally considered as an immunoregulatory cytokine, but accumulating data demonstrate that it also plays a critical role in development of effector immunity. Since TGF- β has a potent ability to alter immune responses, modulation of the TGF-β pathway for treatment of transplantation patients could be effective if carried out in a target selective manner. This review will focus on the role of TGF-β in T cell differentiation and discuss the prospect of TGF-β as the therapeutic target of lung transplantation acceptance.
TGF-β 最初被认为是一种免疫调节细胞因子，但越来越多的证据表明，它在效应免疫的发展中也起着关键作用。由于 TGF-β 具有改变免疫反应的强大能力，如果以靶向选择性的方式对 TGF-β 途径进行调节，那么治疗移植患者可能会有效。本文将重点讨论 TGF-β 在 T 细胞分化中的作用，并探讨 TGF-β 作为肺移植接受治疗靶点的前景。
