Department of Pediatric Nephrology, The First Affiliated Hospital of GuangXi Medical University, NanNing, Guangxi 530021, China.
Ren Fail. 2013;35(4):573-8. doi: 10.3109/0886022X.2013.773834. Epub 2013 Mar 7.
The association between endothelial nitric oxide synthase (eNOS) Glu298Asp gene polymorphism and end-stage renal disease (ESRD) risk is still controversial. A meta-analysis was performed to evaluate the association between eNOS Glu298Asp gene polymorphism and ESRD susceptibility. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic database. Six articles were identified for the analysis of association between eNOS Glu298Asp gene polymorphism and ESRD risk. T allele was associated with ESRD susceptibility in overall populations and in Asians (overall populations: p = 0.01, Asian: p < 0.00001). Furthermore, GG genotype might play a protective role against ESRD onset for overall populations, Asians, and Africans. However, a link between eNOS Glu298Asp gene polymorphism and ESRD risk was not found in Caucasians and Brazil population. In conclusion, T allele might become a significant genetic molecular marker for the onset of ESRD in overall populations, and in Asians. However, more studies should be performed in the future.
内皮型一氧化氮合酶（eNOS）Glu298Asp 基因多态性与终末期肾病（ESRD）风险之间的关联仍存在争议。进行了荟萃分析以评估 eNOS Glu298Asp 基因多态性与 ESRD 易感性之间的关联。通过预设的文献搜索和合格相关研究的选择，从电子数据库中收集数据。确定了六项关于 eNOS Glu298Asp 基因多态性与 ESRD 风险之间关联的分析文章。在总体人群和亚洲人群中，T 等位基因与 ESRD 易感性相关（总体人群：p=0.01，亚洲人：p<0.00001）。此外，GG 基因型可能对总体人群、亚洲人和非洲人发生 ESRD 起到保护作用。然而，在白种人和巴西人群中，没有发现 eNOS Glu298Asp 基因多态性与 ESRD 风险之间的联系。总之，T 等位基因可能成为总体人群和亚洲人群 ESRD 发病的重要遗传分子标志物。然而，未来还需要进行更多的研究。
