Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
Photodiagnosis Photodyn Ther. 2013 Feb;10(1):1-16. doi: 10.1016/j.pdpdt.2012.08.004. Epub 2012 Sep 18.
Photodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are well understood, further advances in anti-angiogenesis require a detailed understanding of PDT effects at the microvasculature level. Although some of the earliest investigations of PDT noted effects on platelet aggregation the importance of their interaction with endothelial cells and the crucial role of various signaling pathways is only now emerging. This review aims to give a general overview of PDT related studies on platelets, vascular effects, and their interaction with endothelial cells to indicate the potential for studies in this area.
光动力疗法（PDT）具有直接的细胞作用和间接的血管作用。这两种作用都已得到充分证实，后者促使 PDT 治疗特别针对血管生成。虽然血管作用已得到充分理解，但要进一步推进抗血管生成，就需要详细了解 PDT 在微血管水平上的作用。尽管最早的一些 PDT 研究注意到了对血小板聚集的影响，但血小板与内皮细胞的相互作用及其各种信号通路的关键作用，直到现在才逐渐显现。本综述旨在概述与血小板、血管作用及其与内皮细胞相互作用相关的 PDT 研究，以表明该领域的研究潜力。
