Clinical and Academic Department of Sleep and Breathing, Royal Brompton & Harefield NHS Foundation Trust, United Kingdom.
Neuromuscul Disord. 2013 Apr;23(4):289-97. doi: 10.1016/j.nmd.2013.01.006. Epub 2013 Mar 7.
Gastrostomy, gastrojejunostomy and anti-reflux surgery in infants and children who are chronically ventilator dependent are associated with significant risk of morbidity and mortality. We report outcomes of 22 high risk children who underwent these procedures at our centre. Pre-operative investigations included: overnight oxygen and carbon dioxide monitoring and subsequent optimisation of ventilatory support, echocardiography, video fluoroscopy, and assessment of gastroesophageal reflux. We carried out 24 procedures under general anaesthesia. Twenty-one children used ventilatory support pre-operatively. Median age of first surgical procedure was 18 months (range 3-180). Supplementary feeding was commenced in 20 children prior to procedure, median age 9 months (1-31). Median PICU length of stay was 1 (1-8) days. No children died in the post-operative period. Extubation was possible within 24h in 87% of cases. Complications included; atelectasis (n=2), ileus (n=2), abdominal distension (n=4) and loose stools (n=1). We conclude that, in this high risk cohort of ventilator dependent children with predominantly neuromuscular disorders, with careful assessment, operative intervention can be carried out under general anaesthesia, with the child being extubated early back onto their routine ventilatory support and aggressive airway clearance. Additionally this protocol can minimise post-operative complications and is associated with a good outcome in the majority.
胃造口术、胃空肠吻合术和抗反流手术在长期依赖呼吸机的婴儿和儿童中与较高的发病率和死亡率相关。我们报告了在我们中心接受这些手术的 22 名高危儿童的结果。术前检查包括:过夜氧气和二氧化碳监测以及随后优化通气支持、超声心动图、视频透视和胃食管反流评估。我们在全身麻醉下进行了 24 次手术。21 名儿童在术前使用通气支持。首次手术的中位年龄为 18 个月(范围 3-180)。20 名儿童在术前开始补充喂养,中位年龄为 9 个月(1-31)。重症监护病房的中位住院时间为 1 天(1-8)。术后无儿童死亡。87%的病例在 24 小时内拔管。并发症包括:肺不张(n=2)、肠梗阻(n=2)、腹胀(n=4)和稀便(n=1)。我们得出结论,在以神经肌肉疾病为主的这种高风险呼吸机依赖儿童队列中,经过仔细评估,手术干预可以在全身麻醉下进行,患儿可以早期拔管回到常规通气支持,并进行积极的气道清除。此外,该方案可以最大限度地减少术后并发症,并在大多数情况下取得良好的结果。