Kvetnanský R, Jahnová E, Torda T, Strbák V, Baláz V, Macho L
Mech Ageing Dev. 1978 Mar;7(3):209-16. doi: 10.1016/0047-6374(78)90067-2.
Male Wistar specific-pathogen-free rats aged 2, 7, 17, 30, 60, 120, 200, 360 and 600 days, all killed in experiment on the same day, were examined. The body weight significantly increased until the 200th day, the weight of adrenals until the 120th day and the adrenal protein content until the 30th day of life. The adrenaline content of the adrenals increased continuously during the 600 days studied. Adrenal noradrenaline content increased rapidly over the first 17 days, remained at a stable level until the 120th day, and rose to a higher level after 200 days. The activity of adrenal catecholamine-synthesizing enzymes also increased with age: tyrosine hydroxylase gradually increased until the 360th day, dopamine-beta-hydroxylase and phenylethanolamine-N-methyl transferase until the 200th day. Our results demonstrate that, in the rat, during development there is a gradual increase of adrenal weight, adrenaline content, tyrosine hydroxylase and phenylethanolamine-N-methyl transferase activity until maturation (120th day), whereas the adrenal noradrenaline content reaches the adult values earlier, around the 17th day. During aging, adrenal catecholamines significantly increase when compared to young-adult rats (120-day-old), probably due to the elevated activity of the adrenal catecholamine-synthesizing enzymes. The increased adrenal catecholamine levels in old animals might be connected with a higher incidence of cardiovascular diseases in aged.
对2日龄、7日龄、17日龄、30日龄、60日龄、120日龄、200日龄、360日龄和600日龄的雄性Wistar无特定病原体大鼠进行了检查，所有大鼠均于同一天在实验中处死。体重在第200天前显著增加，肾上腺重量在第120天前增加，肾上腺蛋白质含量在出生后第30天前增加。在所研究的600天内，肾上腺的肾上腺素含量持续增加。肾上腺去甲肾上腺素含量在最初17天迅速增加，在第120天前保持稳定水平，并在200天后升至更高水平。肾上腺儿茶酚胺合成酶的活性也随年龄增加：酪氨酸羟化酶在第360天前逐渐增加，多巴胺-β-羟化酶和苯乙醇胺-N-甲基转移酶在第200天前增加。我们的结果表明，在大鼠发育过程中，肾上腺重量、肾上腺素含量、酪氨酸羟化酶和苯乙醇胺-N-甲基转移酶活性逐渐增加直至成熟（第120天），而肾上腺去甲肾上腺素含量在第17天左右较早达到成年值。在衰老过程中，与年轻成年大鼠（120日龄）相比，肾上腺儿茶酚胺显著增加，这可能是由于肾上腺儿茶酚胺合成酶活性升高所致。老年动物肾上腺儿茶酚胺水平的升高可能与老年心血管疾病的较高发病率有关。
