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幼年甲状腺功能减退和甲状腺功能亢进大鼠肾上腺中酪氨酸羟化酶活性及儿茶酚胺含量

Tyrosine hydroxylase activity and catecholamine content in the adrenals of young hypo- and hyperthyroid rats.

作者信息

Gripois D, Klein C, Valens M

出版信息

Biol Neonate. 1980;37(3-4):165-71. doi: 10.1159/000241269.

DOI:10.1159/000241269
PMID:6102486
Abstract

The weight, the tyrosine hydroxylase (TH) activity and the catecholamine (noradrenaline and adrenaline) content of young rat adrenals have been measured from birth to 20 days after birth in relation to hypo- and hyperthyroidism. Hypothyroidism impairs the adrenal growth, while hyperthyroidism has no effect on the adrenal weight. Hypothyroidism is associated with an enhancement of TH activity and catecholamine content. In hyperthyroid rats, the increase in TH activity and catecholamine content is slower than in controls. In adult animals, TH activity and catecholamine content are less affected by thyroid function.

摘要

已测定出生至出生后20天幼鼠肾上腺的重量、酪氨酸羟化酶(TH)活性和儿茶酚胺(去甲肾上腺素和肾上腺素)含量,以研究甲状腺功能减退和甲状腺功能亢进的影响。甲状腺功能减退会损害肾上腺生长,而甲状腺功能亢进对肾上腺重量无影响。甲状腺功能减退与TH活性增强和儿茶酚胺含量增加有关。在甲状腺功能亢进的大鼠中,TH活性和儿茶酚胺含量的增加比对照组慢。在成年动物中,TH活性和儿茶酚胺含量受甲状腺功能的影响较小。

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Tyrosine hydroxylase activity and catecholamine content in the adrenals of young hypo- and hyperthyroid rats.幼年甲状腺功能减退和甲状腺功能亢进大鼠肾上腺中酪氨酸羟化酶活性及儿茶酚胺含量
Biol Neonate. 1980;37(3-4):165-71. doi: 10.1159/000241269.
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Experientia. 1983 Apr 15;39(4):430-1. doi: 10.1007/BF01963165.