National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, G. Mazzini Hospital, p.zza Italia 1, 64100 Teramo, Italy.
CNS Neurol Disord Drug Targets. 2013 Mar;12(2):252-64. doi: 10.2174/1871527311312020012.
Oxytocin is a nonapeptide mammalian hormone, best known for its role in childbirth, parturition and lactation. It has been implicated in the control of social behaviors and relationships, such as monogamy or promiscuous behaviors. The putative involvement of oxytocin in schizophrenia was first postulated following several pioneer reports of oxytocin use in schizophrenia and observations of increased oxytocin levels in the cerebrospinal fluid of schizophrenic patients, although this latter finding has subsequently been challenged. More recently, oxytocin plasma levels have been found to be decreased in schizophrenic individuals, particularly in those exhibiting hyponatremic polydipsia and emotional dysregulation. Some authors report that intranasal oxytocin administration to schizophrenic patients may reduce symptomatology. The aim of the present paper was to review studies investigating symptomatology, social cognition and emotion recognition changes in DSM-IV-TR schizophrenic patients, after administration of intranasal oxytocin at different doses. Literature search was conducted in March, 2012. PubMed and Scopus databases were used to find studies for inclusion in the systematic review. Oxytocin may represent an important novel adjunctive treatment for patients with schizophrenia. However, some limitations of current studies cannot be overlooked and further investigations are certainly needed.
催产素是一种九肽哺乳动物激素，以其在分娩、分娩和哺乳中的作用而闻名。它被认为与控制社会行为和关系有关，例如一夫一妻制或滥交行为。催产素在精神分裂症中的潜在作用首先是在几项催产素在精神分裂症中的应用的先驱报告和精神分裂症患者脑脊液中催产素水平升高的观察之后提出的，尽管这后一种发现随后受到了挑战。最近，发现精神分裂症个体的血浆催产素水平降低，特别是在表现出低钠血症多饮和情绪失调的个体中。一些作者报告说，向精神分裂症患者鼻内给予催产素可能会减轻症状。本文的目的是综述研究在不同剂量鼻内给予催产素后，DSM-IV-TR 精神分裂症患者的症状、社会认知和情绪识别变化。文献检索于 2012 年 3 月进行。使用 PubMed 和 Scopus 数据库查找纳入系统评价的研究。催产素可能是精神分裂症患者的一种重要的新型辅助治疗方法。然而，目前研究的一些局限性不容忽视，还需要进一步的研究。
