Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
Org Lett. 2013 Mar 15;15(6):1418-20. doi: 10.1021/ol400357t. Epub 2013 Mar 7.
After almost 100 years, the structure of the product of the reaction between 2,4-diaminotoluene and formaldehyde was elucidated: derivative 3, which we call the Hünlich base, was synthesized on a multigram scale and its enantiomers were easily separated in preparative amounts. Furthermore, transformation of the NH2 groups to the corresponding bis-iodides and bis-azides is presented. The latter was also used for desymmetrization by click chemistry.
经过近 100 年的研究，终于阐明了 2,4-二氨基甲苯与甲醛反应产物的结构：我们称之为亨尼希碱的衍生物 3 已在毫克级规模上合成，其对映异构体也可方便地分离得到。此外，本文还介绍了将 NH2 基团转化为相应的双碘化物和双叠氮化物的方法。后者也可用于点击化学的不对称转化。
