1Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
Angiology. 2013 Nov;64(8):627-32. doi: 10.1177/0003319713480424. Epub 2013 Mar 7.
Atherosclerosis plays an important role in the etiopathogenesis of coronary artery ectasia (CAE). Inflammation markers may play a part in the pathogenesis of CAE. We aimed to assess the association between the CAE and the neutrophil-lymphocyte (N/L) ratio. Consecutive eligible patients (n = 181) were divided into 3 groups: patients with CAE, those with newly diagnosed coronary artery disease (CAD), and those with a normal coronary angiogram. The N/L ratio and mean platelet volume (MPV) were measured as part of the automated complete blood count. There were no statistically significant differences in N/L ratio and MPV between the CAE and the CAD groups. The N/L ratio and MPV were significantly higher in patients in both CAE and CAD groups compared to those in the control group (P < .01). An increased N/L ratio may play a role not only in the pathogenesis of CAD but also in the pathophysiology of CAE.
动脉粥样硬化在冠状动脉扩张（CAE）的病因学中起着重要作用。炎症标志物可能在 CAE 的发病机制中起作用。我们旨在评估 CAE 与中性粒细胞-淋巴细胞（N/L）比值之间的关系。连续符合条件的患者（n = 181）分为 3 组：CAE 患者、新诊断的冠心病（CAD）患者和冠状动脉造影正常的患者。N/L 比值和平均血小板体积（MPV）作为自动全血细胞计数的一部分进行测量。CAE 组和 CAD 组之间的 N/L 比值和 MPV 无统计学差异。与对照组相比，CAE 和 CAD 组患者的 N/L 比值和 MPV 均显著升高（P <.01）。N/L 比值升高不仅可能在 CAD 的发病机制中起作用，而且可能在 CAE 的病理生理学中起作用。
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